Deliberations have begun in the retrial of the murder case.
Knox's conviction was overturned in 2011, freeing her to return to U.S.
The presiding appellate judge who acquitted Knox in the murder of her British roommate says he remains certain there is no evidence of her guilt.
The decision by an Italian court to overturn Knox's acquittal is once again raising concerns both at home and abroad about how justice works in Italy.
The move extended a prolonged legal battle that has raised a host of questions about how the next phase of Italian justice would play out.
Ruled that a Florence appeals court must re-hear case.
Italy's top criminal court is considering whether to overturn her acquittal in the murder of her roommate.
American 'anxious' as prosecutors seek new trial for 2007 murder.